4.8 Article

Metal-Free Reduction of Aromatic and Aliphatic Nitro Compounds to Amines: A HSiCl3-Mediated Reaction of Wide General Applicability

Journal

ORGANIC LETTERS
Volume 17, Issue 16, Pages 3941-3943

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01698

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Funding

  1. Universita degli Studi di Milano
  2. ZaCh System SpA (Zambon Chemicals)

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A new, mild, metal-free, HSiCl3-mediated reduction of both aromatic and aliphatic nitro groups to amines that is of wide general applicability, tolerant of many functional groups, and respectful of the stereochemical integrity of stereocenters is reported.

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