Journal
JOURNAL OF HYPERTENSION
Volume 31, Issue 6, Pages 1144-1150Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e3283604016
Keywords
blood pressure; monounsaturated fatty acids; nutrition; oleic acid; population study
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Funding
- U.S. National Heart, Lung, and Blood Institute, National Institutes of Health (NIH) [2-RO1-HL50490]
- NIH Office on Dietary Supplements, Bethesda, Maryland
- national agencies in China, Japan [the Ministry of Education, Science, Sports, and Culture, Grant-in-Aid for Scientific Research] [090357003]
- National Institute of Health Research (NIHR) Biomedical Research Centre, Imperial College Healthcare NHS Trust
- MRC [G0801056] Funding Source: UKRI
- Medical Research Council [G0801056B, G0801056] Funding Source: researchfish
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Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40-59 years from 17 population samples in China, Japan, UK and USA. Nutrient intake data were based on four in-depth multipass 24-h dietary recalls/person and two-timed 24-h urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1% kcal (China) to 12.2% kcal (USA). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with DBP for all participants; for 2238 'nonintervened' individuals, the relationship was stronger. Estimated DBP differences with 2-SD higher monounsaturated fatty acids (5.35% kcal) were -0.82mmHg (P<0.05) for all participants and -1.70mmHg (P<0.01) for nonintervened individuals. Inverse associations of dietary total oleic acid (main monounsaturated) with blood pressure in nonintervened individuals were not significant, but those of oleic acid from vegetable sources were stronger and significant (P<0.05). Conclusion: Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations.
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