Journal
ORGANIC LETTERS
Volume 17, Issue 20, Pages 5028-5031Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02504
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Funding
- National Natural Science Foundation of China [21262029, 21562037]
- Fok Ying Tong Education Foundation [141116]
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A novel iron-catalyzed dual-oxidative dehydrogenative (DOD) tandem annulation of glycine derivatives with tetrahydrofurans (THFs) for the synthesis of high value quinoline fused lactones has been developed. The reactions were performed under mild reaction conditions. And the use of cheap substrates (glycine derivatives and THF) and an even cheaper simple inorganic iron salt as the catalyst makes this protocol very attractive for potential synthetic applications.
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