4.8 Article

Efficient Synthesis of 3,3′-Mixed Bisindoles via Lewis Acid Catalyzed Reaction of Spiro-epoxyoxindoles and Indoles

Journal

ORGANIC LETTERS
Volume 17, Issue 14, Pages 3430-3433

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01432

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Funding

  1. DST, New Delhi [SR/S1/OC-97/2012]
  2. CBMR, Lucknow
  3. CSIR, New Delhi
  4. UGC, New Delhi

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An efficient strategy for the synthesis of 3-(3-indolyl)-oxindole-3-methanol has been developed to achieve a Lewis acid catalyzed, highly regioselective ring opening of spiro-epoxyoxindoles with indoles. The method is used for the gram-scale formal total synthesis of (+/-)-gliocladin C.

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