Journal
ORGANIC LETTERS
Volume 17, Issue 18, Pages 4510-4513Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02184
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Funding
- Bayer S.A.S.
- CNRS France (Centre National de la Recherche Scientifique)
- University of Strasbourg
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The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C-H acidic compounds is reported. This approach allows for an efficient access to difluoromethylated products of high added value in good to excellent yields and with scale-up possibilities.
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