4.8 Article

Chemoselective Formation of Unsymmetrically Substituted Ethers from Catalytic Reductive Coupling of Aldehydes and Ketones with Alcohols in Aqueous Solution

Journal

ORGANIC LETTERS
Volume 17, Issue 7, Pages 1778-1781

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00553

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Funding

  1. National Science of Foundation [CHE-1358439]
  2. National Institute of Health General Medical Sciences [R15 GM109273]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Chemistry [1265830] Funding Source: National Science Foundation

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A well-defined cationic Ru-H complex catalyzes reductive etherification of aldehydes and ketones with alcohols. The catalytic method employs environmentally benign water as the solvent and cheaply available molecular hydrogen as the reducing agent to afford unsymmetrical ethers in a highly chemoselective manner.

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