4.8 Article

Base-Promoted Cross-Dehydrogenative Coupling of Quinoline N-Oxides with 1,3-Azoles

Journal

ORGANIC LETTERS
Volume 17, Issue 6, Pages 1445-1448

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00330

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Funding

  1. NSF of China [21102133, 21172200]

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An efficient cross-dehydrogenative coupling of quinoline N-oxides and 1,3-azoles has been developed under external oxidant and metal free conditions. The desired products were isolated in good to excellent yields for 26 examples. This methodology provides a practical pathway to biheteroaryls and features high practicality, high efficiency, and environmental friendliness.

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