Journal
ORGANIC LETTERS
Volume 17, Issue 8, Pages 1890-1893Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00571
Keywords
-
Categories
Funding
- EPFL (Switzerland)
- Swiss National Science Foundation (SNSF)
Ask authors/readers for more resources
A copper-catalyzed oxyalkylation of allylic alcohols using nonactivated alkyl nitriles as reaction partners was developed. A sequence involving generation of an alkyl nitrile radical followed by its addition to a double bond and a copper-mediated formation of C(sp(3))-O bond was proposed to account for the reaction outcome. The protocol provided an efficient route to functionalized tri- and tetrasubstituted epoxides via formation of a C(sp(3))C(sp(3)) and a C(sp(3))-O bond with moderate to excellent diastereoselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available