Journal
ORGANIC LETTERS
Volume 17, Issue 3, Pages 748-751Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00043
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Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Canadian Institutes for Health Research (CHIR)
- NSERC
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An entirely solid-phase synthesis of daptomycin, a cyclic lipodepsipeptide antibiotic currently in clinical use, was achieved using a combination of a-azido and Fmoc amino acids. This methodology was applied to the synthesis of several daptomycin analogs, one of which did not contain kynurenine or the synthetically challenging amino acid (2S,3R)-methylglutamate yet exhibited an MIC approaching that of daptomycin.
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