Diastereoselective Synthesis of α-Quaternary Aziridine-2carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters

A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant alpha-quaternary amino esters and derivatives starting from readily available precursors.