Journal
JOURNAL OF HYPERTENSION
Volume 28, Issue 10, Pages 1971-1982Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e32833c6edb
Keywords
blood pressure; human; hypertension; meta-analysis; soy isoflavone supplements; systematic review
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Funding
- Fuji Foundation for Protein Research, Osaka, Japan
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Objective Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans. Methods PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22. Results Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P=0.01) compared with placebo (heterogeneity P=0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect wa
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