Journal
ORGANIC LETTERS
Volume 17, Issue 14, Pages 3442-3445Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01450
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2014CB745100]
- Tianjin Municipal Science & Technology Commission [14JCZDJC33400]
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A facile thermodynamic cyclopropanation of trisubstituted olefinic azlactone with a stock solution of CF3CHN2 in CH3CN is realized. This method shows excellent generality, affording a wide range of trifluoromethyl-substituted cyclopropanes bearing azlactone rings in good to high yields and diastereoselectivities. With the products in hand, the trifluoromethyl-substituted cyclopropane alpha-amino acids and relative peptide derivatives could be readily obtained.
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