4.8 Article

Synthesis of Fluorosugar Reagents for the Construction of Well-Defined Fluoroglycoproteins

Journal

ORGANIC LETTERS
Volume 17, Issue 11, Pages 2836-2839

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01259

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Funding

  1. European Commission
  2. MICINN, Spain
  3. MINECO, Spain [CTQ2011-22872BQU]
  4. Generalitat de Catalunya
  5. Royal Society
  6. Fundacao para a Ciencia a Tecnologia, Portugal
  7. EPSRC
  8. EPSRC [EP/M003647/1] Funding Source: UKRI
  9. Engineering and Physical Sciences Research Council [EP/M003647/1] Funding Source: researchfish

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2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-beta-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such beta-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.

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