Journal
JOURNAL OF HYPERTENSION
Volume 28, Issue 8, Pages 1692-1698Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e32833a6132
Keywords
adolescent; arterial stiffness; elasticity; obesity; type 2 diabetes mellitus
Categories
Funding
- NCRR NIH HHS [UL1 RR026314] Funding Source: Medline
- NHLBI NIH HHS [K23 HL080447-05, R01 HL076269, K23 HL080447, R01 HL076269-04] Funding Source: Medline
Ask authors/readers for more resources
Objective Adults with obesity or obesity-related type 2 diabetes (T2DM) are at higher risk for cardiovascular disease possibly due to increased arterial stiffness. We sought to determine if arterial stiffness is increased in youth with obesity or T2DM as compared with lean controls. Methods Youth age 10-24 years (N=670, 62% non-Caucasian, 35% male) were examined. They were stratified by the 85th% of BMI as lean (L=241), obese (O=234) or obese with T2DM (T2DM=195). Questionnaire, anthropometric, BP, laboratory (fasting glucose, insulin, HbA1c, lipids, CRP), physical activity, and DXA were collected. Brachial artery distensibility (BrachD), pulse wave velocity (PWV) and augmentation index (AIx) were measured. Group differences were evaluated by ANOVA. General linear multivariate models were constructed to elucidate independent determinates of arterial stiffness. Results CV risk profile deteriorated from L to O to T2DM group. There was a progressive increase in AIx and PWV-trunk with progressive decline in BrachD from L to O to T2DM individuals (all P<0.05). Group (status as L, O or T2DM) was an independent predictor of arterial stiffness even after adjusting for CV risk factors. Conclusion Arterial stiffness is increased in young individuals with obesity and obesity-related T2DM even after correction for risk factors. J Hypertens 28: 1692-1698 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available