4.8 Article

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

Journal

ORGANIC LETTERS
Volume 17, Issue 13, Pages 3218-3221

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01307

Keywords

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Funding

  1. Croucher Foundation and Cambridge Trust
  2. MEC-Spain (FPU-predoctoral grants)
  3. Pfizer Worldwide Research and Development
  4. Xunta de Galicia Government
  5. EPSRC [EP/K0099494/1, EP/K039520/1]
  6. EPSRC [EP/K009494/1, EP/K039520/1] Funding Source: UKRI
  7. Engineering and Physical Sciences Research Council [EP/K039520/1, EP/K009494/1] Funding Source: researchfish

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An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.

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