Journal
ORGANIC LETTERS
Volume 17, Issue 15, Pages 3686-3689Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01646
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Funding
- NSFC [21432003, 21202072]
- Fundamental Research Funds for the Central Universities [860976, 861966]
- Major Scientific and Technological Project of Guangdong Province [2011A08030001]
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A highly regioselective intramolecular oxy-fluorination of alkenyl oximes was achieved. This new transformation represents an efficient method for the preparation of monofluoromethyl-substituted isoxazolines. The synthetic application of the oxy-fluorination product was demonstrated by a one-step synthesis of monofluoromethyl-substituted beta-hydroxyl ketone derivatives.
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