Journal
ORGANIC LETTERS
Volume 17, Issue 18, Pages 4468-4471Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02132
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Funding
- MIUR (PRIN) [prot. 2010NRREPL]
- Universita degli Studi di Milano (Piano Sviluppo)
- Marie Curie Integration Grant
- Israel Council for Higher Education
- CAMBER
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The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted beta(2,3)-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the beta amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.
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