Journal
JOURNAL OF HYPERTENSION
Volume 27, Issue 7, Pages 1341-1349Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e32832b521b
Keywords
angiotensin converting enzyme inhibition; angiotensin II antagonism; angiotensin II receptor blockade; chronic kidney disease; kidney ischemia; renin angiotensin aldosterone system; sympathetic nerve activity
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In chronic kidney disease simultaneous activation of the renin - angiotensin and sympathetic systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review firstly summarizes experimental and clinical evidence in chronic kidney disease supporting this idea and addresses the possibility that this mechanism is also relevant in some other disease conditions. J Hypertens 27:1341-1349 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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