Journal
ORGANIC LETTERS
Volume 17, Issue 17, Pages 4236-4239Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02020
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Funding
- National Natural Science Foundation of China [21272085, 21472056]
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A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenyl-quinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved consecutive iron-mediated [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cydization, oxidation, and copper-catalyzed denitrogenation sequences. The formed structure is the privileged core in drugs and bioactive molecules.
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