4.8 Article

Nickel-Catalyzed Formal Homocoupling of Methoxyarenes for the Synthesis of Symmetrical Biaryls via C-O Bond Cleavage

Journal

ORGANIC LETTERS
Volume 17, Issue 24, Pages 6142-6145

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03151

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Funding

  1. MEXT, Japan
  2. ACT-C from JST, Japan
  3. Grants-in-Aid for Scientific Research [15H02177] Funding Source: KAKEN

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A new method has been developed for the nickel-catalyzed homocoupling of methoxyarenes via bond cleavage using a diboron reagent The use of 1,3-dicyclohexylimidazol-2-ylidene as a ligand was found to be critical to the success of the reaction. This new method allows the synthesis of a wide range of biaryl compounds.

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