Journal
ORGANIC LETTERS
Volume 17, Issue 18, Pages 4514-4517Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02208
Keywords
-
Categories
Funding
- UCSB
- Amgen
- NIH Shared Instrumentation grant (SIG) [1S10OD012077-01A1]
Ask authors/readers for more resources
The first example of a general asymmetric nitrosocarbonyl hetero-ene reaction is described. The procedure uses a copper-catalyzed aerobic oxidation of a commercially available chiral nitrosocarbonyl precursor (EleNOr) and is operationally simple. The transformation is both high yielding and highly diastereoselective for a range of silyl enol ether derivatives. A variety of synthetically useful postfunctionalization reactions are presented along with a mechanistic rationale that can be used as a predictive model for future asymmetric reactions with nitrosocarbonyl intermediates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available