4.8 Article

Tetra-n-butylammonium Iodide Catalyzed C-H Azidation of Aldehydes with Thermally Stable Azidobenziodoxolone

Journal

ORGANIC LETTERS
Volume 17, Issue 21, Pages 5212-5215

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02543

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Funding

  1. JSPS [24790024, 15K07852]
  2. Asahi Glass Foundation
  3. National Science Foundation [CHE-1262479]
  4. Grants-in-Aid for Scientific Research [24790024, 15K07852] Funding Source: KAKEN

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Tetra-n-butylammonium iodide can efficiently catalyze direct azidation of aldehyde C-H bonds with thermally stable azidobenziodoxolone at room temperature. Compared to conventional methods, which require excessive amounts of highly explosive azide sources, this is a safe and convenient procedure.

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