Journal
ORGANIC LETTERS
Volume 17, Issue 12, Pages 3062-3065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01346
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Funding
- National Science Centre (Poland) [UMO-2011/01/D/ST5/05869, UMO-2012/05/E/ST5/03893]
- Ministry of Science and Higher Education (Poland) [DI2012 008942]
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The synthesis and reactivity of a novel class of clickable nucleotide analogues containing a C-phosphonate subunit that has an alkyne group at the terminal position of the oligophosphate chain are reported. The C-phosphonate subunits were prepared by simple one- or two-step procedures using commercially available reagents. Nucleotides were prepared by MgCl2-catalyzed coupling reactions and then subjected to CuAAC reactions with various azide compounds to afford 5'-gamma-labeled nucleoside triphosphates in excellent yields.
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