Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 2, Pages 361-364Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02172j
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Funding
- National Natural Science Foundation of China [21172106, 21372114]
- National Basic Research Program of China [2010CB923303]
- Research Fund for the Doctoral Program of Higher Education of China [20120091110010]
- Natural Science Foundation of China [21272178]
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Radical cyanomethylation/arylation of arylacrylamides to access oxindoles with acetonitrile as the radical precursor is described. This reaction involves dual C-H bond functionalization, including the sp(3) C-H of acetonitrile and the sp(2) C-H of the phenyl group. A variety of functional groups, such as methoxy, ethyloxy carbonyl, chloro, bromo, iodo, nitro, trifluoromethoxy and trifluoromethyl groups, are well tolerated.
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