Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 25, Pages 6935-6939Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00858a
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Funding
- Shanghai Municipal Health Bureau young scientific research project [20144Y0055]
- Shanghai Committee of Science and Technology, China [14ZR1437500, 13431900702]
- NSFC [81371958, 81321092]
- SKLDR/SIMM [SIMM1403ZZ-01]
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An efficient and practical approach to trifluoromethylthiolation of alpha-haloketones/alpha-haloarylmethanes was developed. The transformation employs only AgSCF3 and KI in situ generated active nucleophilic trifluoromethylthio species and cleanly occurs in up to quantitative yield at room temperature, thereby providing an unprecedentedly easy entry to various alpha-SCF3-substituted ketones/arylmethanes.
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