Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 13, Pages 3866-3870Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00212e
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- Deutsche Forschungsgemeinschaft [BE4572/2-1]
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We present the concept, synthesis, and kinetic characterization of PYRROC as the first functionalized cycloalkyne which cannot form isomers in the reaction with azides. In aqueous buffer, PYRROC displays unprecedented rate accelerations in SPAAC of three to four orders of magnitude, leading to rate constants exceeding 400 M-1 s(-1).
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