Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 39, Pages 9894-9906Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob01405k
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Funding
- CNRS
- Universite de Montpellier
- Ecole Nationale Superieure de Chimie de Montpellier
- Ligue contre le Cancer (comite des Pyrenees-Orientales)
- LabEx CheMISyst [ANR-10-LABX-05-01]
- ANR [ANR-11-PDOC-002-02]
- French Ministere de la Recherche
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Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.
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