4.6 Article

Alkynylation of heterocyclic compounds using hypervalent iodine reagent

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 10, Pages 2884-2889

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02625j

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Funding

  1. Czech Science Foundation [P207/10/0428]
  2. Charles University Grant Agency [427011]

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The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.

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