Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 5, Pages 1507-1514Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01605j
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Funding
- National Natural Science Foundation of China [81273358]
- Program for Innovative Research Team of the Ministry of Education
- Program for Liaoning Innovative Research Team in University
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A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound 3t possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound 3t significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.
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