Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 9, Pages 2634-2639Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02462a
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Funding
- National Natural Science Foundation of China [31470421, 31270396]
- State Key Laboratory of Applied Organic Chemistry
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A novel anticancer prodrug compound 1, which was designed to be triggered by thick and release the chemotherapeutic agent mechlorethamine, was successfully prepared and evaluated for the first time The activation of compound 1 was determined by NMR analysis and denaturing alkaline agarose gel electrophoresis. A fluorescence image and comet assay indicated that the inducible reactivity of 1 could be accomplished in cell media. The anticancer activities are also discussed.
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