Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 7, Pages 2044-2054Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02417f
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Funding
- Knut and Alice Wallenberg Foundation
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A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.
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