Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 30, Pages 8298-8309Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob01174d
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Funding
- Innovative Medicines Initiative Joint Undertaking [115360]
- European Union
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Pd-mediated C-H bond functionalisation protocols have been designed and developed on tryptophan derivatives and tryptophan-containing peptides. The examination of different arylation reactions (three sets of different conditions A-C), all of which are notable for their low temperatures (<= 40 degrees C), allowed identification of unified and complementary synthetic approaches toward a series of functionalised tryptophan-containing products. Tryptophan-containing peptides demonstrated to be susceptible to aromatic oxidation were successfully and selectively modified through the application of diaryliodonium salts in good yields.
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