4.5 Review

Impact of standardised review of intravenous antibiotic therapy 72 hours after prescription in two internal medicine wards

Journal

JOURNAL OF HOSPITAL INFECTION
Volume 74, Issue 4, Pages 326-331

Publisher

W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2009.07.011

Keywords

Antibiotic consumption; Antimicrobial stewardship; Quality of healthcare

Funding

  1. Swiss National Science Foundation [32-63128.00]
  2. Centre Hospitaller Universitaire Vaudois, Lausanne, Switzerland

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Post-prescription review of hospital antibiotic therapy may contribute to more appropriate use. We estimated the impact of a standardised review of intravenous antibiotic therapy three days after prescription in two internal medicine wards of a university hospital. In one ward, we assessed the charts of patients under intravenous antibiotic therapy using a standardised review process and provided feedback to the prescriber. There was no intervention in the other ward. After six months we crossed the allocation between the two wards. In all, 204 courses of antibiotic therapy were included in the intervention periods and 226 in the control periods. Post-prescription review led to proposals for modification in 46% of antibiotic courses. Time to treatment modification was 22% shorter in the intervention periods compared with the control periods (3.9 +/- 5.2 days vs 5.0 +/- 6.0 days, P = 0.007). Patients included in the intervention group had lower antibiotic consumption than patients in the control group, but the intervention had no significant impact on the overall antibiotic consumption of the two wards. (C) 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

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