Related references
Note: Only part of the references are listed.Somatic mutational analysis of FAK in breast cancer: A novel gain-of-function mutation due to deletion of exon 33
Xu-Qian Fang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
M. H. A. M. van Miltenburg et al.
BRITISH JOURNAL OF CANCER (2014)
Focal adhesion kinase An alternative focus for anti-angiogenesis therapy in ovarian cancer
Rebecca L. Stone et al.
CANCER BIOLOGY & THERAPY (2014)
FAK dimerization controls its kinase-dependent functions at focal adhesions
Karen Brami-Cherrier et al.
EMBO JOURNAL (2014)
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
Christine Jean et al.
JOURNAL OF CELL BIOLOGY (2014)
FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth
Isabelle Tancioni et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy
Bernardo Tavora et al.
NATURE (2014)
Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship
Irina M. Shapiro et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
FAK in cancer: mechanistic findings and clinical applications
Florian J. Sulzmaier et al.
NATURE REVIEWS CANCER (2014)
Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities
Tracy Thennes Schmidt et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)
Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics
Ming Luo et al.
CANCER RESEARCH (2013)
The Role of Snail in EMT and Tumorigenesis
Yifan Wang et al.
CURRENT CANCER DRUG TARGETS (2013)
Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step
Michael Herman Chui
INTERNATIONAL JOURNAL OF CANCER (2013)
Transforming growth factor-β1 induces epithelial-mesenchymal transition and integrin α3β1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug
Daishi Saito et al.
JOURNAL OF BIOCHEMISTRY (2013)
Nuclear FAK: a new mode of gene regulation from cellular adhesions
Ssang-Taek Steve Lim
MOLECULES AND CELLS (2013)
TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer
M. K. Wendt et al.
ONCOGENE (2013)
Band 4.1 proteins regulate integrin-dependent cell spreading
Youngsin Jung et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Expression of focal adhesion kinase in small-cell lung carcinoma
Sebahat Ocak et al.
CANCER (2012)
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo
Vita M. Golubovskaya et al.
CARCINOGENESIS (2012)
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
Wenjun Guo et al.
CELL (2012)
VEGF-Induced Vascular Permeability Is Mediated by FAK
Xiao Lei Chen et al.
DEVELOPMENTAL CELL (2012)
The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells
Alan Serrels et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated
Baotran Ho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression
Ssang-Taek Lim et al.
JOURNAL OF CELL BIOLOGY (2012)
Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors
Jeffrey R. Infante et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Focal adhesion kinase and tumour angiogenesis
Tanguy Lechertier et al.
JOURNAL OF PATHOLOGY (2012)
Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer
Cha Kyong Yom et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo
Xu Peng et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2011)
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells
Xiao-Yan Li et al.
JOURNAL OF CELL BIOLOGY (2011)
Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment
Jayme B. Stokes et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF
Zhe Chen et al.
PROTEIN SCIENCE (2011)
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
Isabelle Tanjoni et al.
CANCER BIOLOGY & THERAPY (2010)
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models
Colin Walsh et al.
CANCER BIOLOGY & THERAPY (2010)
TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
Judit Anido et al.
CANCER CELL (2010)
Endothelial FAK is required for tumour angiogenesis
Bernardo Tavora et al.
EMBO MOLECULAR MEDICINE (2010)
Targeting Pyk2 for therapeutic intervention
Christopher A. Lipinski et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2010)
Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer
Joo Hyun Park et al.
HUMAN PATHOLOGY (2010)
Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation
Zhe Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation
Ssang-Taek Lim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
Xiaofeng Zhao et al.
JOURNAL OF CELL BIOLOGY (2010)
Cell mechanics and the cytoskeleton
Daniel A. Fletcher et al.
NATURE (2010)
The FERM domain: organizing the structure and function of FAK
Margaret C. Frame et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
Vita M. Golubovskaya et al.
BMC CANCER (2009)
Signal transduction by focal adhesion kinase in cancer
Jihe Zhao et al.
CANCER AND METASTASIS REVIEWS (2009)
Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells
Ming Luo et al.
CANCER RESEARCH (2009)
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
Steven N. Hochwald et al.
CELL CYCLE (2009)
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
Shi-Wen Luo et al.
EMBO JOURNAL (2009)
Autophosphorylation-independent and -dependent Functions of Focal Adhesion Kinase during Development
Jean-Marc Corsi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model
Jill K. Slack-Davis et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
Tsukasa Shibue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer
Paolo P. Provenzano et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271
Walter Gregory Roberts et al.
CANCER RESEARCH (2008)
FERM control of FAK function - Implications for cancer therapy
Ssang-Taek Lim et al.
CELL CYCLE (2008)
Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-time PCR analyses
Elizabeth A. Beierle et al.
CLINICAL CANCER RESEARCH (2008)
TGF beta-induced EMT requires focal adhesion kinase (FAK) signaling
Carla Cicchini et al.
EXPERIMENTAL CELL RESEARCH (2008)
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
Sara M. Weis et al.
JOURNAL OF CELL BIOLOGY (2008)
A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth
Vita M. Golubovskaya et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
Ssang-Taek Lim et al.
MOLECULAR CELL (2008)
Focal Adhesion Kinase Versus p53: Apoptosis or Survival?
William G. Cance et al.
SCIENCE SIGNALING (2008)
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
Hicham Lahlou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma
Jyotsnabaran Halder et al.
CANCER RESEARCH (2007)
Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland
Tamas Nagy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural basis for the autoinhibition of focal adhesion kinase
Daniel Lietha et al.
CELL (2007)
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth
Qing Shi et al.
MOLECULAR CARCINOGENESIS (2007)
Cellular characterization of a novel focal adhesion kinase inhibitor
Jill K. Slack-Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
Ta-Jen Liu et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Identification of pancreatic cancer stem cells
Chenwei Li et al.
CANCER RESEARCH (2007)
Integrin-regulated FAK-Src signaling in normal and cancer cells
Satyajit K. Mitra et al.
CURRENT OPINION IN CELL BIOLOGY (2006)
Organization and post-transcriptional processing of focal adhesion kinase gene
Jean-Marc Corsi et al.
BMC GENOMICS (2006)
Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number
Marta Canel et al.
CLINICAL CANCER RESEARCH (2006)
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
L Patrawala et al.
ONCOGENE (2006)
Clinical significance of focal adhesion kinase in resectable pancreatic cancer
K Furuyama et al.
WORLD JOURNAL OF SURGERY (2006)
Crystal structure of the FERM domain of focal adhesion kinase
DFJ Ceccarelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
R Braren et al.
JOURNAL OF CELL BIOLOGY (2006)
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype
AL Lark et al.
MODERN PATHOLOGY (2005)
FAK-mediated Src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation
XY Wu et al.
DEVELOPMENTAL CELL (2005)
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
VM Golubovskaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
TL Shen et al.
JOURNAL OF CELL BIOLOGY (2005)
Focal adhesion kinase: In command and control of cell motility
SK Mitra et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
GW McLean et al.
GENES & DEVELOPMENT (2004)
Biological significance of focal adhesion kinase in ovarian cancer - Role in migration and invasion
AK Sood et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Regulation of endothelial cell function by Fak and Pyk2
AW Orr et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2004)
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction
LA Cooper et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients
SE Theocharis et al.
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY (2003)
Phosphatidylinositol phosphate kinase type 1γ and β1-Integrin cytoplasmic domain bind to the same region in the talin FERM domain
IL Barsukov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
T Miyazaki et al.
BRITISH JOURNAL OF CANCER (2003)
Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model
PJ Kaplan-Lefko et al.
PROSTATE (2003)
Prospective identification of tumorigenic breast cancer cells
M Al-Hajj et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
v-Src SH3-enhanced interaction with focal adhesion kinase at β1 integrin-containing invadopodia promotes cell invasion
CR Hauck et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The focal adhesion kinase - A regulator of cell migration and invasion
CR Hauck et al.
IUBMB LIFE (2002)
Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression
R Stanzione et al.
LABORATORY INVESTIGATION (2001)
The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells - Involvement of death receptor-related signaling pathways
LH Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
FAK integrates growth-factor and integrin signals to promote cell migration
DJ Sieg et al.
NATURE CELL BIOLOGY (2000)
RAFTK/Pyk2-mediated cellular signalling
H Avraham et al.
CELLULAR SIGNALLING (2000)