4.2 Review

Understanding the Roles of FAK in Cancer: Inhibitors, Genetic Models, and New Insights

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Somatic mutational analysis of FAK in breast cancer: A novel gain-of-function mutation due to deletion of exon 33

Xu-Qian Fang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Oncology

Focal adhesion kinase An alternative focus for anti-angiogenesis therapy in ovarian cancer

Rebecca L. Stone et al.

CANCER BIOLOGY & THERAPY (2014)

Article Biochemistry & Molecular Biology

FAK dimerization controls its kinase-dependent functions at focal adhesions

Karen Brami-Cherrier et al.

EMBO JOURNAL (2014)

Article Multidisciplinary Sciences

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

Bernardo Tavora et al.

NATURE (2014)

Article Cell Biology

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Irina M. Shapiro et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Oncology

FAK in cancer: mechanistic findings and clinical applications

Florian J. Sulzmaier et al.

NATURE REVIEWS CANCER (2014)

Article Physiology

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

Tracy Thennes Schmidt et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Article Oncology

The Role of Snail in EMT and Tumorigenesis

Yifan Wang et al.

CURRENT CANCER DRUG TARGETS (2013)

Review Biochemistry & Molecular Biology

Nuclear FAK: a new mode of gene regulation from cellular adhesions

Ssang-Taek Steve Lim

MOLECULES AND CELLS (2013)

Article Biochemistry & Molecular Biology

Band 4.1 proteins regulate integrin-dependent cell spreading

Youngsin Jung et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

Wenjun Guo et al.

Article Cell Biology

VEGF-Induced Vascular Permeability Is Mediated by FAK

Xiao Lei Chen et al.

DEVELOPMENTAL CELL (2012)

Article Cell Biology

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

Ssang-Taek Lim et al.

JOURNAL OF CELL BIOLOGY (2012)

Review Oncology

Focal adhesion kinase and tumour angiogenesis

Tanguy Lechertier et al.

JOURNAL OF PATHOLOGY (2012)

Review Biochemistry & Molecular Biology

Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo

Xu Peng et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2011)

Article Medicine, Research & Experimental

Endothelial FAK is required for tumour angiogenesis

Bernardo Tavora et al.

EMBO MOLECULAR MEDICINE (2010)

Review Pharmacology & Pharmacy

Targeting Pyk2 for therapeutic intervention

Christopher A. Lipinski et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2010)

Article Biochemistry & Molecular Biology

Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

Zhe Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Multidisciplinary Sciences

Cell mechanics and the cytoskeleton

Daniel A. Fletcher et al.

NATURE (2010)

Review Cell Biology

The FERM domain: organizing the structure and function of FAK

Margaret C. Frame et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Oncology

Signal transduction by focal adhesion kinase in cancer

Jihe Zhao et al.

CANCER AND METASTASIS REVIEWS (2009)

Article Biochemistry & Molecular Biology

Autophosphorylation-independent and -dependent Functions of Focal Adhesion Kinase during Development

Jean-Marc Corsi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

Tsukasa Shibue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Cell Biology

FERM control of FAK function - Implications for cancer therapy

Ssang-Taek Lim et al.

CELL CYCLE (2008)

Article Oncology

TGF beta-induced EMT requires focal adhesion kinase (FAK) signaling

Carla Cicchini et al.

EXPERIMENTAL CELL RESEARCH (2008)

Article Cell Biology

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

Sara M. Weis et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

Ssang-Taek Lim et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Focal Adhesion Kinase Versus p53: Apoptosis or Survival?

William G. Cance et al.

SCIENCE SIGNALING (2008)

Article Multidisciplinary Sciences

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

Hicham Lahlou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Structural basis for the autoinhibition of focal adhesion kinase

Daniel Lietha et al.

Article Biochemistry & Molecular Biology

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

Qing Shi et al.

MOLECULAR CARCINOGENESIS (2007)

Article Biochemistry & Molecular Biology

Cellular characterization of a novel focal adhesion kinase inhibitor

Jill K. Slack-Davis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Oncology

Identification of pancreatic cancer stem cells

Chenwei Li et al.

CANCER RESEARCH (2007)

Article Cell Biology

Integrin-regulated FAK-Src signaling in normal and cancer cells

Satyajit K. Mitra et al.

CURRENT OPINION IN CELL BIOLOGY (2006)

Article Biotechnology & Applied Microbiology

Organization and post-transcriptional processing of focal adhesion kinase gene

Jean-Marc Corsi et al.

BMC GENOMICS (2006)

Article Surgery

Clinical significance of focal adhesion kinase in resectable pancreatic cancer

K Furuyama et al.

WORLD JOURNAL OF SURGERY (2006)

Article Biochemistry & Molecular Biology

Crystal structure of the FERM domain of focal adhesion kinase

DFJ Ceccarelli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

VM Golubovskaya et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Cell Biology

Focal adhesion kinase: In command and control of cell motility

SK Mitra et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Biochemistry & Molecular Biology

Regulation of endothelial cell function by Fak and Pyk2

AW Orr et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2004)

Article Biochemistry & Molecular Biology

Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

LA Cooper et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Oncology

Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients

SE Theocharis et al.

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY (2003)

Article Biochemistry & Molecular Biology

Phosphatidylinositol phosphate kinase type 1γ and β1-Integrin cytoplasmic domain bind to the same region in the talin FERM domain

IL Barsukov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Endocrinology & Metabolism

Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model

PJ Kaplan-Lefko et al.

PROSTATE (2003)

Article Multidisciplinary Sciences

Prospective identification of tumorigenic breast cancer cells

M Al-Hajj et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

v-Src SH3-enhanced interaction with focal adhesion kinase at β1 integrin-containing invadopodia promotes cell invasion

CR Hauck et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

The focal adhesion kinase - A regulator of cell migration and invasion

CR Hauck et al.

IUBMB LIFE (2002)

Article Medicine, Research & Experimental

Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression

R Stanzione et al.

LABORATORY INVESTIGATION (2001)

Article Cell Biology

FAK integrates growth-factor and integrin signals to promote cell migration

DJ Sieg et al.

NATURE CELL BIOLOGY (2000)

Review Cell Biology

RAFTK/Pyk2-mediated cellular signalling

H Avraham et al.

CELLULAR SIGNALLING (2000)