Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 63, Issue 2, Pages 88-98Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155414561329
Keywords
locally advanced cervical squamous cell carcinoma; radiation resistance; osteopontin; E-cadherin; epithelial-mesenchymal transition; immunohistochemistry
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Funding
- National Natural Science Foundation of China [81372792, 81225013, 81101193]
- Hunan Department of Science and Technology Foundation [2013SK2019]
- Freedom Explore Fund for the Doctoral Program of Central South University [2013zzts089]
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Radiotherapy is the first-line treatment for all stages of cervical cancer, whether it is used for radical or palliative therapy. However, radioresistance of cervical cancer remains a major therapeutic problem. Consequently, we explored if E-cadherin (a marker of epithelial-mesenchymal transition) and osteopontin could predict radioresistance in patients with locally advanced cervical squamous cell carcinoma (LACSCC). Patients were retrospectively reviewed and 111 patients divided into two groups (radiation-resistant and radiation-sensitive groups) according to progression-free survival (PFS). In pretreated paraffin-embedded tissues, we evaluated E-cadherin and osteopontin expression using immunohistochemical staining. The percentage of patients with high osteopontin but low E-cadherin expression in the radiation-resistant group was significantly higher than those in the radiation-sensitive group (p<0.001). These patients also had a lower 5-year PFS rate (p<0.001). Our research suggests that high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with LACSCC ([Hazard ratios (95% CI) 6.766 (2.940, 15.572)], p<0.001).
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