4.6 Article

PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 11, Pages 3457-3461

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00029g

Keywords

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Funding

  1. National Natural Science Foundation of China [21272087, 21472058, 21232003, 21202053]
  2. National Basic Research Program of China [2011CB808603]

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A PhI(OAc)(2)-promoted radical cyclization of beta,gamma-unsaturated hydrazones and oximes has been developed for an efficient synthesis of various valuable pyrazoline and isoxazoline derivatives with satisfactory yields (up to 96%) under mild conditions.

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