Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 59, Issue 5, Pages 540-556Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155411404073
Keywords
lipid droplet; leukocytes; macrophages; inflammation; innate immunity; eicosanoids; adipose differentiation-related protein; electron microscopy; fluorescence microscopy; imaging techniques
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil) [481970/2010-0]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, Brazil) [CBB-APQ-01294-08, CBB PPM 00508/10]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- National Institutes of Health, United States [AI033372, AI020241, AI051645, AI022571]
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Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases. These organelles are actively formed in vivo within cells from the immune system, such as macrophages, neutrophils, and eosinophils, in response to different inflammatory conditions and are sites for synthesis and storage of inflammatory mediators. In this review, the authors discuss structural and functional aspects of LBs and current imaging techniques to visualize these organelles in cells engaged in inflammatory processes, including infectious diseases. The dynamic morphological aspects of LBs in leukocytes as inducible, newly formable organelles, elicitable in response to stimuli that lead to cellular activation, contribute to the evolving understanding of LBs as organelles that are critical regulators of different inflammatory diseases, key markers of leukocyte activation, and attractive targets for novel anti-inflammatory therapies. (J Histochem Cytochem 59:540-556, 2011)
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