4.6 Article

Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 19, Pages 5376-5380

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00617a

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Funding

  1. National Natural Science Foundation of China [21402071]
  2. Foundation of Kunming University of Science and Technology [KKSY201426046]

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A novel and facile Cu-catalyzed addition/cyclization cascade of o-cyanoarylacrylamide was developed. The process exhibits significant functional group tolerance, and provides an efficient and straightforward pathway for the synthesis of various phosphonylated quinoline-2,4(1H, 3H)-diones.

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