Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 51, Issue -, Pages E84-E88Publisher
WILEY-BLACKWELL
DOI: 10.1002/jhet.1823
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Funding
- Natural Science Foundation of Hubei Provincial Department of Science and Technology [2011CDB08301]
- Science Research Project of Hubei University of Medicine [2011 CXX03, 2009QDJ15]
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Thieno[2,3-d]pyrimidinones were reported to act as potent anticancer agents; in this work, a series of new substituted thieno[2,3-d]pyrimidinone (6) were synthesized via the aza-Wittig reaction in satisfactory yields. The structures of these compounds were confirmed by elemental analysis, IR, 1H-NMR, and mass spectral data, and compound 6h was further analyzed by single crystal X-ray diffraction. Cytotoxic effect of all the compounds was carried out on human breast and lung cancer cell lines (MCF-7 and SPC-A-1, A459). Compound 6f exhibited the best inhibition activities against A459 with IC50 4.1M.
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