Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 50, Issue 3, Pages 519-527Publisher
WILEY
DOI: 10.1002/jhet.1513
Keywords
Thiazole; Pyrazole; Hantzch reaction; Vilsmeier Haack reaction; Antimicrobial activity
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Funding
- UGC, New Delhi
- BCUD, University of Pune, India
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A series of new 1-[4-(2,3,4-substituted-phenyl) thiazol-2-yl]-3-(2,3,4-substituted-phenyl)-1H-pyrazole-4-carbaldehyde (), 4-[4-(4-substituted-phenyl) thiazol-2-yl]-3-(4-substituted-phenyl)-1-phenyl-1H-pyrazole (), 4-[4-(4-substituted phenyl)thiazol-2-yl]-1-phenyl-1H-pyrazol-3-amine () have been synthesized by using Vilsmeier Haack formylation and Hantzsch reaction in high yield. All the synthesized compounds were tested qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the synthesized compounds showed potent antimicrobial activity against gram positive and gram negative bacteria as well as fungi species.
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