4.4 Article

Dimethylformamide Catalyzed Synthesis of Novel HeterocyclesTheir Characterization and Antimicrobial Evaluation

Journal

JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 50, Issue 2, Pages 403-407

Publisher

WILEY-BLACKWELL
DOI: 10.1002/jhet.1073

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Indandione 1 was brominated to yield 2-bromoIndandione 2, which further reacted with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol, and triazole to furnished 3-substituted aniline-2-thia-4-aza-6,7-benzo-8-oxo-bicyclo[3.3.0]-1(5),3-octadiene 3, 3-substituted aniline-2-oxa-4-aza-6,7-benzo-8-oxo-bicyclo[3.3.0]-1(5),3-octadiene 4, 2-Thia-5-aza-9-oxo-3,4-(3-substituted) benzo-7,8-benzo-bicyclo[4.3.0]-1(6) nonene 5, 2-oxa-5-aza-9-oxo-(3, 4)-(7,8)-dibenzo-bicyclo[4.3.0]-1(6) nonene 6, 3-substituted-(1,2,4)triazolo[5,6-b][indeno(2,3-e)]-1,3,4-thiadiazine 7, respectively. The structures of compounds were elucidated on the basis of spectral techniques, further the representative compounds were screened for their antimicrobial activity.

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