Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 50, Issue 5, Pages 1108-1115Publisher
WILEY-BLACKWELL
DOI: 10.1002/jhet.1586
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A synthesis, characterization, and antimicrobial study of a novel benzodipyran analog of chloramphenicol was carried out. Structure-antimicrobial activity relationship study indicates that benzodipyran analog of chloramphenicol was most active against Gram-positive bacteria, Staphylococcus aureus, and the fungal strains Rhizoctonia bataticola and Penicillium even at minimum inhibitory concentration 10 mu g/mL and showed moderate activity in other bacterial and fungal organisms. All the compounds synthesized during the present investigation were characterized by IR, 1H NMR, 13C NMR, ESI-MS, and elemental analysis.
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