Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 50, Issue 6, Pages 1290-1293Publisher
WILEY
DOI: 10.1002/jhet.1560
Keywords
epigoitrin; chemical synthesis; antiviral; antithyroid
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Funding
- Chinese National Science Foundation [81072514]
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Epigoitrin is one of the major components of several natural species, including Isatis indigotica Fort, turnip, and cabbage. It presents antithyroid and antivirus activities. Here, we report an efficient and practical method for the chemical synthesis of epigoitrin from commercially available (R)-(+)-4-hydroxy-gamma-butyrolactone.
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