An Efficient One-Pot Synthesis of Dispiropyrrolidine Derivatives Through 1,3-Dipolar Cycloaddition Reactions Under Ultrasound Irradiation

A series of dispiropyrrolidine derivatives were synthesized via the three-component 1,3-dipolar cycloaddition reaction of isatin, sarcosine and 5-arylidene-1,3-thiazolidine-2,4-dione or 5-arylidene-4-thioxo-1,3- thiazolidine-2-one in ethanol under ultrasound irradiation. This protocol has the advantages of mild reaction conditions, higher yields, and shorter reaction time.