A Facile and Efficient Synthesis of Bis(oxazoline)s

Thiophene-2,5-dicarboxylic acid, benzene-1,3-dicarboxylic acid, or furan-2,5-di-carboxylic acid, respectively, reacted with various beta-amino alcohols in toluene under reflux within 24 h, to form nine bis(oxazoline)s (1-3) in good yields through water deprivation via a one-pot reaction. The synthetic method is facile and efficient and deserves great application potentials in the research and development in the area of bis(oxazoline)s.