Synthesis of 2-Arylquinolin-4(1H)-ones and Their Transformation to N-Alkylated and O-Alkylated Derivatives

2-Aryl-4-quinolones are versatile synthetic intermediates and several articles continue to appear in literature describing their synthesis, chemical transformation, structural properties, and biological activities. Their versatility as synthetic intermediates is a consequence of 4-quinolone moiety, which contains several reactive centers (positions 1, 3, and 4) for possible functionalization and can also enable different degree of unsaturation. In this review, we describe methods developed to-date for the synthesis of 2-arylquinotin-4(1H)-ones and their N-alkylated and O-alkylated derivatives.