Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 46, Issue 6, Pages 1425-1429Publisher
WILEY
DOI: 10.1002/jhet.238
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Funding
- National Natural Science Foundation of China [20572032, 90713008]
- Chanachun Discovery Sciences
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To enhance the iron-chelating ability of P-3A, 4-aminoquinazolines were designed as conformation-restricted bleomycin analogs. An efficient method was developed to prepare the 4-aminoquinazoline heterocyclic nucleus, which entails a two-step one-pot procedure leading to 4-aminoquinazolines in good yields. The application of this method to synthesis 4-aminoquinazoline bleomycin analogs is envisioned.
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