Journal
JOURNAL OF HEREDITY
Volume 102, Issue -, Pages S11-S18Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jhered/esr042
Keywords
agouti; black and tan; canid; coat color; pigmentation; saddle tan; wolf sable
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Funding
- Natural Science and Engineering Research Council of Canada [464048-2010]
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Agouti Signaling Protein (ASIP) controls the localized expression of red and black pigment in the domestic dog through interaction with other genes, such as Melanocortin 1 Receptor and Beta-Defensin 103. Specific ASIP alleles are necessary for many of the coat color patterns, such as black-and-tan and saddle tan. Mutations in 2 ASIP alleles, a(y) and a, have previously been identified. Here, we characterize a mutation consisting of a short interspersed nuclear element (SINE) insertion in intron 1 of ASIP that allows for the differentiation of the a(n') wolf sable and a(t) black-and-tan alleles. The SINE insertion is present in dogs with the a(t) and a alleles but absent from dogs with the a(n') and a(y) alleles. Dogs with the saddle tan phenotype were all a(t)/a(t). Schnauzers were all a(n')/a(n'). Genotypes of 201 clogs of 35 breeds suggest that there are only 4 ASIP alleles, as opposed to the 5 or 6 predicted in previous literature. These data demonstrate that the dominance hierarchy of ASIP is a(y) > a(n') > a(t) > a.
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