Journal
JOURNAL OF HEPATOLOGY
Volume 61, Issue 5, Pages 1158-1165Publisher
ELSEVIER
DOI: 10.1016/j.jhep.2014.06.034
Keywords
Cirrhosis; Liver; Health related quality of life; Quality of life
Categories
Funding
- European Commission Framework 7 programme under the large-scale integrating project d-LIVER [287596]
- NIHR Newcastle Biomedical Research Centre at The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- Medical Research Council [MR/L001489/1, MR/K02325X/1, G0500020, MR/K501037/1] Funding Source: researchfish
- National Institute for Health Research [IS-BRC-0211-10046, NF-SI-0513-10091] Funding Source: researchfish
- NIHR Newcastle Biomedical Research Centre [BH141402, BH134330, BH121729, BH137357] Funding Source: researchfish
- MRC [G0500020, MR/L001489/1] Funding Source: UKRI
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Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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