Journal
JOURNAL OF HEPATOLOGY
Volume 58, Issue 5, Pages 984-992Publisher
ELSEVIER
DOI: 10.1016/j.jhep.2013.01.006
Keywords
Lipogenesis; Cholesterol; LXR; Polyunsaturated fatty acids; Steatosis
Categories
Funding
- INRA-FORMAS France-Sweden cooperative program
- Region Midi-Pyrenees
- ANR
- Ministere de l'Enseignement Superieur et de la Recherche
Ask authors/readers for more resources
Background & Aims: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. Methods: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. Results: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. Conclusions: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency. (c) 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available